By Mafalda Pardal, Elle Wadsworth, Beau Kilmer

Potent synthetic opioids, illegally produced, are starting to emerge in Europe. Considering the damaging harms caused by the opioid crisis in North America, which has led to a substantial surge in overdose deaths, it is crucial that European leaders understand the challenges associated with synthetic opioids. In this Perspective, we present and discuss the current situation in Europe concerning synthetic opioids, and draw on earlier and ongoing crises involving this group of substances to reflect on likely challenges ahead and ways to improve preparedness.

Santa Monica, CA: RAND, 2024. 20p.

By Jonathan P. Caulkins and Keith Humphreys

If, in 2015, someone had told you that the number of overdose deaths caused solely by the two most historically lethal drugs—heroin and cocaine—would drop by more than half by 2021, you would likely have assumed that the overdose crisis in the U.S. was finally coming to an end. Instead, drug overdose deaths soared to more than 100,000 per year due to the rise of synthetic drugs, a truly disruptive innovation with which U.S. drug policy is only beginning to grapple.

To clarify the key term: synthetic drugs are substances that can be produced in a lab and are not from plant-derived components. In Canadian and U.S. illegal opioid markets, synthetic fentanyl and its analogues are outcompeting heroin, which is made from the poppy plant. These synthetics claimed the lives of more than 70,000 Americans in 2021 (out of 106,699 total drug-involved overdose deaths, or 66%), either by themselves or in combination with other drugs.[1] Methamphetamine, another synthetic, has attained a larger share of the stimulant market than cocaine, which is made from coca leaves.[2] The rapid expansion of synthetic tranquilizers—such as xylazine and benzodiazepines—has spread addiction and death, particularly when these drugs are used in combination with opioids. The U.S. is also facing a bevy of so-called new psychoactive substances (NPS), such as MDMA and mephedrone, that collectively attract more users than do older, “minor” drugs such as LSD, GHB, and PCP.

Drug policy analysts, including the authors of this brief, are swamped with requests from desperate policymakers, clinicians, parents, and activists to find solutions to the problem of synthetic drugs. This brief comprises our answer. Unfortunately, it is not particularly upbeat. All four traditional pillars of drug policy—enforcement, treatment, harm reduction, and prevention—have limits, and there is no simple solution for the synthetic drug market. Nonetheless, the nation can do some things better and should stop doing other things that are harmful. Policymakers must:

• Maintain prohibition of the production and sale of synthetic drugs

• Expect law enforcement to shrink market-related harms, such as violence, but not necessarily to shrink the supply of the drugs themselves

• Keep expanding medication-assisted treatment and access to naloxone

• Embrace the shunning of illegal drugs as a cultural norm

• Be generous toward those who are struggling, including those suffering from drug addiction

Unfortunately, the widespread availability of potentially lethal temptations in the U.S. may be the new normal, and overdose deaths will continue to remain higher than historical norms. Such realism is depressing but honest, and honesty is the best foundation for policy.

New York: Manhattan Institute, 2023. 13p.

By C4ADS

The illicit synthetic drug networks that fuel the ongoing opioid epidemic in the United States continue to evolve and adapt to changing incentives and pressures, finding innovative ways to exploit technology and increased global interconnectivity. The digital age, in particular, has had a transformative role in allowing synthetic drug networks to take root. Fentanyl networks are among the world’s first digital native drug networks. Global internet connectivity has opened a new era of drug distribution by facilitating direct-to-consumer transactions, rapid reaction to enforcement trends, and the delivery of retail, rather than wholesale, drug volumes through licit commercial delivery services.

C4ADS investigated these drug supply chains, conducting extensive multilingual analysis of Chinese corporate entities, the clear web, and social media, in order to better understand the methods by which they operate.

Washington, DC: C4ADS 2020, 45p.

by Richard Chelin

Synthetic drugs have created a public-health crisis and changed drug market dynamics in the country. Synthetic drugs, more specifically, new psychoactive substances (NPSs), were first detected in Mauritius in 2013 and since then have had a significant negative impact, overtaking heroin as the most popular drug among young people. The government has developed various policies to address the issue, the most recent being the National Drug Control Masterplan, which promotes collaboration among law enforcement agencies. However, the success of the strategy will depend on its effective implementation.

ENACT-Africa, 2020. 20p.

By Francisco Cuamea

Until 2012, when the United States gradually began the regulation and decriminalization of marijuana, Mexican cartels had secured a decades-long monopoly on the US cannabis market. As they became displaced from that market, the cartels scaled up their production of synthetic drugs, such as crystal methamphetamine, which is produced in clandestine laboratories that are generally set up in remote locations in the mountains, rural areas or small towns. The rich biodiversity that surrounds these sites is affected by the chemical waste resulting from crystal meth production that is dumped near these labs. In addition to the crystal meth market, Mexican organized crime groups also entered the black market in endangered marine species and industries built on other high-value species. Organized crime groups have begun to leave a significant environmental and social footprint, accelerating the disappearance of certain marine species and the disintegration of fishing communities.

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  One of the affected regions is the Sea of Cortez, also known as the Gulf of California, made up of the Mexican states of Baja California, Baja California Sur, Nayarit, Sinaloa and Sonora, which together contribute 11% of the country’s gross domestic product and are united by the immense gulf of north-western Mexico, declared a world heritage site by UNESCO. According to UNESCO, the Sea of Cortez comprises 244 islands, islets and coastal areas. It contains 695 vascular plant species and 891 types of fish, of which 90 are endemic. The number of plant species is much higher than those recorded at any other island or marine site on the World Heritage List. The region is home to 39% of the world’s total number of marine mammal species and 33% of the global number of cetacean species. The region also contains a wealth of endangered land flora and fauna as well as examples of intangible cultural heritage, many of which come from the indigenous peoples of north-western Mexico, such as the Yaqui, the Cora and the Cucapá.6 This brief explores the threat that illicit economic activities pose to biodiversity and ecosystems in the Sea of Cortez region, as well as to some of the area’s most vulnerable communities, those that depend on the fishing industry.

Geneva, SWIT: Global Initiative Against Transnational Organized Crime (GI-TOC), 2023. 17p.

Steven Dudley – Victoria Dittmar – Sara García, Jaime López-Aranda, Annie Pforzheimer, and Ben Westhoff

Precursor chemicals pose an unprecedented challenge for governments and multilateral organizations seeking to mitigate the development, manufacturing, production, and distribution of illicit synthetic drugs. As opposed to most legacy drugs -- which rely on plants, harvests, favorable weather, significant and varied manual labor, and transport of bulk amounts of illicit substances across heavily-policed terrain -- synthetic drugs can be produced in laboratories all year-round using a wide variety of mostly sparsely or unevenly regulated chemicals, which can be employed at different stages of the process in rudimentary laboratories and transported in large or small amounts, often without the knowledge of the transporters themselves. The sources for these chemicals span the globe. They are currently concentrated in China, where a relatively small number of companies appear to be producing precursor chemicals, in mainly two provinces. These chemicals are marketed and sold on the internet, where an army of online providers offer well-regulated and unregulated chemicals via the Clearnet and the dark web. These marketers are sometimes extensions of these same production companies and sometimes independent. Some are also clans, which appear to own numerous production and marketing companies. The precursors are transported to Mexico via cargo ships or air cargo, traveling direct or via circuitous routes. Cargo is often mislabeled, camouflaging the contents, purpose, or amount of their shipment. In Mexico, brokers and independent buyers facilitate this trade, filing paperwork, creating fictitious companies, or bribing officials.

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  The chemicals then make their way to small producers. Often referred to as “cooks,” these producers synthesize the precursors into illicit synthetic drugs that are then sold to large buyers and transport specialists. Two large criminal networks buy and move synthetic drugs in bulk: the Sinaloa Cartel and Jalisco Cartel New Generation (Cartel de Jalisco Nueva Generación – CJNG). These networks are responsible for bringing this product across the most difficult part of its journey and thus charge a premium for their services. After they sell the drugs wholesale, they are largely absent, leaving the distribution and retail sales to other local criminal networks. The precursor industry -- and the synthetic drug industry writ large -- is so challenging to disrupt precisely because it works across legal and illegal spheres, involves many layers and different criminal networks, and has many means to obtain its final objective: the sale of synthetic drugs to an increasing number of consumers. …

Washington, DC: InSight Crime, 2023. 147p.

By Jason Eligh

The report provides an analytical summary of meth markets that is grounded in data collected in 10 countries across the region with details of specific retail price points, commentary on domestic meth distribution systems and structures, and discussion of common structural characteristics across the region that enable and sustain these markets. Furthermore, the data generated from research undertaken for this report is intended to contribute to the broader regional objective of constructing an open-source database of time-series, country-specific illicit commodity price data, where applicable and practicable.

Geneva: Global Initiative Against Transnational Organized Crime, 2021. 104p,

By Steven Dudley, Victoria Dittmar, Sara García, Jaime López-Aranda, Annie Pforzheimer, and Ben Westhoff 

 Precursors are transported to Mexico via cargo ships or air cargo, traveling direct or via circuitous routes. Cargo is often mislabeled, camouflaging the contents, purpose, or amount of their shipment. In Mexico, brokers and independent buyers facilitate this trade, filing paperwork, creating fictitious companies, or bribing officials. The chemicals then make their way to small producers. Often referred to as “cooks,” these producers synthesize the precursors into illicit synthetic drugs that are then sold to large buyers and transport specialists. Two large criminal networks buy and move synthetic drugs in bulk: the Sinaloa Cartel and Jalisco Cartel New Generation (Cartel de Jalisco Nueva Generación - CJNG). These networks are responsible for bringing this product across the most difficult part of its journey and thus charge a premium for their services. After they sell the drugs wholesale, they are largely absent, leaving the distribution and retail sales to other local criminal networks.

The precursor industry -- and the synthetic drug industry writ large -- is so challenging to disrupt precisely because it works across legal and illegal spheres, involves many layers and different criminal networks, and has many means to obtain its final objective: the sale of synthetic drugs to an increasing number of consumers. Those consumers are not just in the United States where synthetic drugs -- in particular fentanyl -- are responsible for tens of thousands of drug overdoses per year. Places like Mexico are experiencing a dramatic uptick in synthetic drug consumption, mostly methamphetamine but also fentanyl. The synthetic drug industry is also having ill effects on the environment in Mexico and is behind a surge in violence in the corridors where it is trafficked and sold on the local markets.

The problem requires governments to rethink their traditional strategies for fighting illicit drugs. In addition to developing regional and global coalitions to monitor and regulate the chemicals, governments must enlist private industry to play a much more active role in mitigating the trade and limiting the spread of these destructive substances.

Washington DC: InSight Crime, 2023. 147p.

By United Nations Office on Drugs and Crime (UNODC)

The versatility of synthetic drugs and flexibility of their manufacture is driving a constant evolution of the illicit synthetic drug market. The dynamic nature of the market continues to present a significant challenge globally, requiring a multifaceted, comprehensive approach to address the problem. In November 2021, UNODC launched the Synthetic Drug Strategy as a framework to support countries in developing evidence and science-based responses to address this ongoing challenge. The strategy includes four spheres of action, namely, multilateralism and international cooperation, early warning on emerging synthetic drug threats, promoting science-informed health responses, and strengthening counter-narcotic interventions. East and Southeast Asia, which is home to one of the largest methamphetamine markets in the world, is a key region for implementation of the strategy. Amidst the continued impact of the COVID-19 pandemic and other recent developments, organised crime groups in the region have shown their adaptability and ingenuity to capitalise on the situation and expand their operations.

Vienna: UNODC, Global SMART Programme , 2022. 36p.

By The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)

This report provides a technical review of the current body of knowledge regarding synthetic cannabinoids that are monitored by the EU Early Warning System. The aim of this report is to strengthen situational awareness of synthetic cannabinoids in Europe and to help stakeholders prepare for, and respond to, public health and social threats caused by such substances.

Lisbon: European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), 2021. 70p.

By Vanda Felbab-Brown

This paper explores policy options for responding to the supply of heroin and synthetic opioids from Mexico to the United States. Forced eradication of opium poppy has been the dominant response to illicit crop cultivation in Mexico for decades. Forced eradication appears to deliver fast results in suppressing poppy cultivation, but the suppression is not sustainable even in the short term. Farmers find a variety of ways to adapt and replant after eradication. Moreover, eradication undermines public safety and rule of law efforts in Mexico, both of high interest to the United States….Unless security and rule of law in Mexico significantly improve, the licensing of opium poppy in Mexico for medical purposes is unlikely to reduce the supply of heroin to the United States. Mexico faces multiple feasibility obstacles for getting international approval for licensing its poppy cultivation for medical purposes, including, currently, the inability to prevent opium diversion to illegal supply and lack of existing demand for its medical opioids. In seeking to establish such demand, Mexico should avoid setting off its own version of medical opioid addiction.

Washington, DC: The Brookings Institution,2020. 28p.

By United Nations Office on Drugs and Crime (UNODC)

The report provides a regional analysis of the key trends and emerging developments of the synthetic drugs and NPS market as well as options for response in Latin America and the Caribbean. Over the past years, the synthetics drug market has experienced a massive expansion and diversification in the region and seen a rapid emergence of a wide range of NPS.

The latest developments include an expanding methamphetamine market, growing concerns around the non-medical use of ketamine, the emergence of fentanyl and MDMA manufacture, as well as new “ecstasy” trends such as higher dosed MDMA tablets and new forms of presentation such as crystalline MDMA. Moreover, the report sheds light on the comparatively high prevalence of use of hallucinogens in the region and the high prevalence of use of tranquilizers among women.

Vienna: UNODC, 2021. 56p.